Medications
Metoclopramide - Reglan
Reglan tablets are indicated for the:
• Treatment for 4 to 12 weeks of symptomatic, documented gastroesophageal reflux in adults who fail to respond to conventional therapy.
• Relief of symptoms in adults with acute and recurrent diabetic gastroparesis.
• Most common adverse reactions (> 10%) are restlessness, drowsiness, fatigue, and lassitude.
• Antipsychotics: Potential for additive effects, including TD, EPS, and NMS; avoid concomitant use.
• CNS depressants: Increased risk of CNS depression. Avoid concomitant use and monitor for adverse reactions.
• Strong CYP2D6 inhibitors (e.g., quinidine, bupropion, fluoxetine, and paroxetine)
• MAO inhibitors: Increased risk of hypertension; avoid concomitant use.
• Tardive Dyskinesia (TD), Other Extrapyramidal Symptoms (EPS), and Neuroleptic Malignant Syndrome (NMS): Avoid concomitant use of other drugs known to cause TD/EPS/NMS and avoid use in patients with Parkinson’s Disease. If symptoms occur, discontinue Reglan and seek immediate medical attention.
• Depression and suicidal ideation/suicide: Avoid use.
