Medications
Deutetrabenazine - Austedo
Uses
Side Effects
Interactions
Precautions
Uses
AUSTEDO is a vesicular monoamine transporter 2 (VMAT2) inhibitor indicated for the treatment of chorea associated with Huntington’s disease
Side Effects
Most common adverse reactions (>8% of AUSTEDO-treated patients and greater than placebo) were: somnolence, diarrhea, dry mouth, and fatigue
Interactions
- Concomitant use of strong CYP2D6 inhibitors: Maximum recommended dose of AUSTEDO is 36 mg per day (18 mg twice daily)
- Alcohol or other sedating drugs: May have additive sedation and somnolence
Precautions
- Neuroleptic Malignant Syndrome (NMS): Discontinue if this occurs
- Akathisia, agitation, restlessness, and parkinsonism: Reduce dose or discontinue if this occurs
- Sedation/somnolence: May impair the patient’s ability to drive or operate complex machinery
