Treatment of panic disorder with or without agoraphobia in adults.
The most common adverse reactions reported in clinical trials for generalized anxiety disorder and panic disorder (incidence >5% and at least twice that of placebo) include: impaired coordination, hypotension, dysarthria, and increased libido.
Use with Opioids: Increase the risk of respiratory depression.
Use with Other CNS Depressants: Produces additive CNS depressant effects.
Use with Digoxin: Increase the risk of digoxin toxicity.
Use with CYP3A Inhibitors (except ritonavir): Increase the risk of adverse reactions of alprazolam.
Use with CYP3A Inducers: Increase the risk of reduced efficacy of alprazolam.
Effects on Driving and Operating Machinery: Patients receiving XANAX should be cautioned against operating machinery or driving a motor vehicle, as well as avoiding concomitant use of alcohol and other central nervous system (CNS) depressant drugs.
Neonatal Sedation and Withdrawal Syndrome (NOWS): Use of XANAX during pregnancy can result in neonatal sedation and neonatal withdrawal syndrome.
Patients with Depression: Exercise caution in patients with signs or symptoms of depression. Prescribe the least number of tablets feasible to avoid intentional overdosage.