Medications
Pimavanserin - Nuplazid
Uses
Side Effects
Interactions
Precautions
Uses
NUPLAZID is an atypical antipsychotic indicated for the treatment of hallucinations and delusions associated with Parkinson’s disease psychosis.
Side Effects
Most common adverse reactions (≥5% and twice the rate of placebo): peripheral edema and confusional state.
Interactions
- Strong CYP3A4 Inhibitors (e.g., ketoconazole): Reduce NUPLAZID dose by one-half.
- Strong CYP3A4 Inducers: Monitor for reduced efficacy. Increase in NUPLAZID dosage may be needed.
Precautions
- QT Interval Prolongation: Increases in QT interval; avoid use with drugs that also increase the QT interval and in patients with risk factors for prolonged QT interval.
