AMRIX is a muscle relaxant indicated as an adjunct to rest and physical therapy for relief of muscle spasm associated with acute, painful musculoskeletal conditions.
Limitations of Use:
AMRIX should be used only for short periods (up to 2 or 3 weeks)
AMRIX has not been found effective in the treatment of spasticity
or cerebral palsy

Most common adverse reactions (incidence ≥3% in any treatment group and greater than placebo): dry mouth, dizziness, fatigue, constipation, nausea, dyspepsia, and somnolence

MAO Inhibitors: Life-threatening interactions may occur
Serotonergic Drugs: Serotonin syndrome has been reported

CNS Depressants: Effects of alcohol, barbiturates, and other CNS depressants may be enhanced
Tramadol: Seizure risk may be enhanced
Guanethidine: Antihypertensive effect may be blocked

Serotonin syndrome has been reported with cyclobenzaprine when used in combination with other serotonergic drugs
Cyclobenzaprine is structurally related to tricyclic antidepressants which have been reported to produce adverse cardiovascular effects or CNS depressant effects
Use in the elderly is not recommended
Use in patients with hepatic impairment is not recommended
Use with caution in patients with a history of urinary retention, angle-closure glaucoma, increased intraocular pressure and in patients taking anticholinergic medications